I personally love running the off-tackle play against the 5-3 defense from an I formation leading with the FB on the OLB and TB trailing cutting off the block. My play side TE or Slot blocks EMOL and everyone else block GOD. This play works really good when you Nasty split the TE and widen the OTs splits too.
All the books say Gut plays also work well against the 5-3 defense because the middle of the defense is weak between the guards. A FB inside trap play might work well or just a tough up the gut FB run. You can also run an ISO on the MLB.
As far as the passing game. The flats are weak. Quick Slants and TE quick passes will work well.
If the DE an OLB crash and bite on inside dives then run sweeps. If the DE is boxing wide, then run an ISO on the OLB.
Like I have written earlier. Every defense has a weakness. They key to good defensive play is to mix it up so the offense can’t figure your defense out.
Play for Fun and Winning is Funner.
Ft Worth, Texas